PREPRINTS AND PUBLICATIONS

V. Nguyen, C. Özden, K. Dong, A. Torres-Ocampo, N. Dziedzic, D. Flaherty, J. Huang, S. Sankura, N. Abromson, D. Tomchick, J. Chen, S. Garman, M.M. Stratton, (2024) A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation. bioRxiv. Download PDF

X. Yang..., V. Nguyen..., M.M. Stratton..., R. Daly, (2024) Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically ‘actionable’ signalling axis in triple negative breast cancer. bioRxiv. Download PDF

D. Narayan..., R. Adafia..., M.M. Stratton..., S. Solbak (2024) Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking and kinase inhibition. bioRxiv. Download PDF

P. Rigter..., M. Dunn..., M.M. Stratton..., G. van Woerden (2024) Role of CAMK2D in neurodevelopment and associated conditions. [PubMed]

C. Özden, S. MacManus, R. Adafia, A. Samkutty, A.P. Torres-Ocampo, S.C. Garman, M.M. Stratton, (2024) Ca2+/CaM dependent protein kinase II (CaMKII)α and CaMKIIβ hub domains adopt distinct oligomeric states and stabilities. Protein Science. ; 33(4):e4960. [PubMed] Download PDF

C. Özden, R. Sloutsky, T. Mitsugi, N. Santos, E. Agnello, C. Gaubitz, J. Foster, E. Lapinskas, E.A. Esposito, T. Saneyoshi, B.A. Kelch, S.C. Garman, Y. Hayashi, M.M. Stratton, (2021) CaMKII binds both substrates and activators at the active site, Cell Reports, 40, 111064. [PubMed] Download PDF

R. Sloutsky and M. M. Stratton, (2020) Functional Implications of CaMKII Alternative Splicing, The European Journal of Neuroscience, 28, 10.1111/ejn.14761. [PubMed] Download PDF

A. P. Torres‐Ocampo, C. Özden, A. Hommer, A. Gardella, E. Lapinskas, A. Samkutty, E. Esposito, S. Garman, M. M. Stratton, (2020) Characterization of CaMKIIα holoenzyme stability, Protein Science, 6, 1524-1534. [PubMed] Download PDF

R. Sloutsky*, N. Dziedzic*, M. J. Dunn, R. M. Bates, A. P. Torres-Ocampo, S. Boopathy, B. Page, J.G. Weeks, L. H. Chao, M. M. Stratton, (2019) Heterogeneity in human hippocampal CaMKII transcripts reveals an allosteric role for the hub domain in activity regulation, Science Signaling, 13, 641, eaaz0240. [PubMed] Download PDF

G. Ardestani, M. C. West, T. J. Maresca, R. A. Fissore, M. M. Stratton, (2019) FRET-based sensor for CaMKII activity (FRESCA): A useful tool for assessing CaMKII activity in response to Ca2+ oscillations in live cells, J Biol Chem, 31, 11876-11891. [PubMed] Download PDF

M. S. Eriksen, O. Nikolanienko, E. I. Hallin, S. Grødem, H. J. Bustad, M. I. Flydal, R. O’Connell, T. Hosokawa, D. Lascu, S. Akerkar, J. Cuéllar, J. J. Chambers, G. Muruganandam, R. Loris, T. Kanhema, Y. Hayashi, M. M. Stratton, J. M. Valpuesta, P. Kursula, A. Martinez, C. R. Bramham, (2019) Molecular determinants of Arc oligomerization and formation of virus-like capsids, bioRxiv, 667956. [bioRxiv] Download PDF

T. Saneyoshi, H. Matsuno, A. Suzuki, H. Murakoshi, N. G. Hedrick, E. Agnello, R. O’Connell, M. M. Stratton, R. Yasuda, Y. Hayashi, (2019) Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP, Neuron, 102, 6, P1199-1210.E6. [PubMed] Download PDF

M. Bhattacharyya*, M. M. Stratton*, Catherine Going*, Yongjian Huang, Ethan McSpadden, Anna Elleman, Pawel Burkhwat, Tiago Barros, Evan Williams, John Kuriyan, (2016) Molecular Mechanism of activation-triggered subunit exchange in human CaMKII, eLife, e13405. [PubMed] Download PDF

M. M. Stratton*, I. H. Lee*, M. Bhattacharyya, S. M. Christensen, L. H. Chao, H. Schulman, J. T. Groves, J. Kuriyan, (2014) Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity, eLife, 3:e01610. [PubMed] Download PDF

M. M. Stratton, L. H. Chao, H. Schulman, J. Kuriyan, (2013) Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II, Current opinion in structural biology, 23, 292-301. [PubMed] Download PDF

L. H. Chao, M. M. Stratton, I. H. Lee, J. Levitz, D. Mandell, T. Kortemme, H. Schulman, J. Kuriyan, (2011) A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme, Cell, 146, 732-745. [PubMed] Download PDF

M. M. Stratton*, S. McClendon*, D. Eliezer, and S. N. Loh, (2011) Structural characterization of two alternate conformations in a Calbindin D9k-based molecular switch, Biochemistry, 50, 5583-5589. [PubMed] Download PDF

M. M. Stratton and S. N. Loh, (2011) Converting a protein into a switch for biosensing and functional regulation, Protein Science, 20, 19-29. [PubMed] Download PDF

M. M. Stratton and S.N. Loh, (2010) On the mechanism of protein fold-switching by a molecular sensor, Proteins, 78, 3260-3269. [PubMed] Download PDF

M. M. Stratton, T. A. Cutler, J. H. Ha, and S. N. Loh, (2010) Probing local structural fluctuations in myoglobin by size-dependent thiol-disulfide exchange, Protein Science, 19, 1587-1594. [PubMed] Download PDF

M. M. Stratton, D. M. Mitrea and S. N. Loh, (2008) A Ca2+-sensing molecular switch based on alternate frame protein folding, ACS Chem. Biol., 3, 723-732. [PubMed] Download PDF

*these authors contributed equally to this work